Postulating the subcortical organization of human consciousness provides a critical link for the construal of pain in patients with impaired cortical function or cortical immaturity during early development. Practical implications of the centrencephalic proposal include the redefinition of pain, improved pain assessment in nonverbal humans, and benefits of adequate analgesia/anesthesia for these patients, which certainly justify the rigorous scientific efforts required. (Published Online May 1 2007).

Illustrations: Numerous Colour and 15 B/w Illustrations Description: The volumes of the PROJECT OF HISTORY OF SCIENCE, PHILOSOPHY AND CULTURE IN INDIAN CIVILIZATION aim to discover the central aspects of India's heritage and present them in an interrelated manner. In spite of their unitary look, these volumes recognize the difference between the areas of material civilization and those of ideational culture. The Project is not being executed by a single group of thinkers, methodologically uniform or ideologically identical in their commitments. (...) Rather, contributions are made by different scholars of diverse ideological persuasions and methodological approaches. The Project is marked by what may be called 'methodological pluralism'. In spite of its primarily historical character, this project, both in its conceptualization and execution, has been shaped by scholars drawn from different disciplines. It is the first time that an endeavour of such unique and comprehensive character has been undertaken to study critically a major world civilization. History of art, unlike that of science, is not an accumulation of facts. It comprises concurrences and overlappings cutting across the linearity of time. Based on this premise the essays in this volume delve into the discourse as also forms of creativity in the Indian tradition in terms of both the perennial and the ephemeral aspects of aesthetic experience. The essays form four groups dealing with (a) core concepts which permeate the discourse on aesthetic theories, and having ramifications in many other disciplines and domains; (b) The Rasa theory in the framework of classical philosophical traditions of Vedanta, Mimamsa, Samkhya, and Kashmir Saivism, and (c) the comprehension of the foundational concepts of aesthetic theory, namely, Rasa and Dhvani from the perspectives of Indian thought traditions addressing also music, dance and the visual arts. There is no clear-cut demarcation between the four groups of essays though in their own framework they illustrate a transition from the discourse (sastra) to practice (prayoga) i.e., from theorizing on the nature of aesthetic experience to the process of concretizing it into forms of music, dance, architecture, and painting. The contributions highlight the fact that the history of Indian aesthetic tradition comprises various textual and performing traditions that have flourished in the Indian subcontinent. What we have is not a single history but multiple histories based on various philosophical and methodological approaches adopted by art historians. Some of these histories pertain to the technical details of a given art form, and some with the changes that have occurred in the evolution and development these forms. While some historical accounts focus on the relevant biographical details of the artists, some art histories focus on the social, cultural, political, and even the economic conditions of civilization that determine the nature of an art form. Considering the multi-dimensional and multi-level complexities of Indian civilization and culture, the contributions to this volume have investigated into a number of factors which are directly and indirectly relevant for comprehending the complexities of the Indian aesthetic tradition. (shrink)

Introduction of deep neural networks to the machine translation research ameliorated conventional machine translation systems in multiple ways, specifically in terms of translation quality. The ability of deep neural networks to learn a sensible representation of words is one of the major reasons for this improvement. Despite machine translation using deep neural architecture is showing state-of-the-art results in translating European languages, we cannot directly apply these algorithms in Indian languages mainly because of two reasons: unavailability of the good corpus and (...) Indian languages are morphologically rich. In this paper, we propose a neural machine translation (NMT) system for four language pairs: English–Malayalam, English–Hindi, English–Tamil, and English–Punjabi. We also collected sentences from different sources and cleaned them to make four parallel corpora for each of the language pairs, and then used them to model the translation system. The encoder network in the NMT architecture was designed with long short-term memory (LSTM) networks and bi-directional recurrent neural networks (Bi-RNN). Evaluation of the obtained models was performed both automatically and manually. For automatic evaluation, the bilingual evaluation understudy (BLEU) score was used, and for manual evaluation, three metrics such as adequacy, fluency, and overall ranking were used. Analysis of the results showed the presence of lengthy sentences in English–Malayalam, and the English–Hindi corpus affected the translation. Attention mechanism was employed with a view to addressing the problem of translating lengthy sentences (sentences contain more than 50 words), and the system was able to perceive long-term contexts in the sentences. (shrink)

The aim of this report is to present an example of a multidisciplinary Indian-Swedish co-operation on ethics in health care. It is based on a conference held in Asia Plateau, Panchgani, Maharasthra, India in 1998. The emphasis is on ethical values that are important for consumers of health care and professionals, and also for different cultures in developed and developing countries. The importance of human dignity is stressed. Sixteen recommendations are given in an appendix.

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Two of the most important contributions that Bimal Krishna Matilal made to comparative philosophy are his doctoral dissertation The Navya-Nyāya Doctrine of Negation: The Semantics and Ontology of Negative Statements in Navya-Nyāya Philosophy and his classic: Perception: An Essay on Classical Indian Theories of Knowing. In this essay, we aim to carry forward the work of Bimal K. Matilal by showing how ideas in classical Indian philosophy concerning absence and perception are relevant to recent debates in Anglo-analytic philosophy. In particular, (...) we focus on the recent debate in the philosophy of perception centering on the perception of absence. In her Seeing Absence, Anya Farennikova argues for the thesis that we literally see absences. Her thesis is quite novel within the contexts of the traditions that she engages: analytical philosophy of perception, phenomenology, and cognitive neuroscience. In those traditions there is hardly any exploration of the epistemology of absence. By contrast, this is not the case in classical Indian philosophy where the debate over the ontological and epistemological status of absence is longstanding and quite engaging. In what follows, we engage Farennikova’s arguments, and those of John-Rémy Martin and Jérome Dokic in their response to her work. Using the work of Matilal, Bilimoria and Shaw we show that there are several engaging ideas that can be taken from Indian philosophy into the terrain explored by Farennikova, and Martin & Dokic. Our aim is to provide an updated comparative engagement on absence and its perception for the purposes of enhancing future discussions within global philosophy. However, we do not aim to do this merely by focusing on the history of primary texts or on twentieth century commentary on primary texts. Instead, we hope to show that the living tradition of Indian philosophy that Matilal embodied carries forward in his students and colleagues as they revive, revise, and extend Indian philosophy. (shrink)

The aim of this paper is to develop the theory of groups definable in the p-adic field ${{\mathbb {Q}}_p}$, with “definable f-generics” in the sense of an ambient saturated elementary extension of ${{\mathbb {Q}}_p}$. We call such groups definable f-generic groups.So, by a “definable f-generic” or $dfg$ group we mean a definable group in a saturated model with a global f-generic type which is definable over a small model. In the present context the group is definable over ${{\mathbb {Q}}_p}$, and (...) the small model will be ${{\mathbb {Q}}_p}$ itself. The notion of a $\mathrm {dfg}$ group is dual, or rather opposite to that of an $\operatorname {\mathrm {fsg}}$ group (group with “finitely satisfiable generics”) and is a useful tool to describe the analogue of torsion-free o-minimal groups in the p-adic context.In the current paper our group will be definable over ${{\mathbb {Q}}_p}$ in an ambient saturated elementary extension $\mathbb {K}$ of ${{\mathbb {Q}}_p}$, so as to make sense of the notions of f-generic type, etc. In this paper we will show that every definable f-generic group definable in ${{\mathbb {Q}}_p}$ is virtually isomorphic to a finite index subgroup of a trigonalizable algebraic group over ${{\mathbb {Q}}_p}$. This is analogous to the o-minimal context, where every connected torsion-free group definable in $\mathbb {R}$ is isomorphic to a trigonalizable algebraic group [5, Lemma 3.4]. We will also show that every open definable f-generic subgroup of a definable f-generic group has finite index, and every f-generic type of a definable f-generic group is almost periodic, which gives a positive answer to the problem raised in [28] of whether f-generic types coincide with almost periodic types in the p-adic case. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Considering CertificationAnand Jayprakash Vaidya (bio)Jewel of Reflection on the Truth about Epistemology: A Complete and Annotated Translation of the Tattva-cintā-maṇi. Volume 1, Perception. Volume 2, Inference. Translated by Stephen Phillips. London: Bloomsbury.I. IntroductionStephen Phillips' Jewel of Reflection on the Truth about Epistemology is a masterful translation and commentary on the books originally written by Gaṅgeśa, the fourteenth-century father of the Navya-Nyāya tradition of Indian philosophy. Jewel is one of (...) the most highly regarded works in Indian epistemology, one that rivals the work of Immanuel Kant in terms of its depth and significance. While J. N. Mohanty (1966) and B. K. Matilal (1968) translated portions of Gaṅgeśa's Jewel, only Phillips (2020) offers a complete translation—one that will serve as the foundation for any future study of Gaṅgeśa. In what follows, I will not be focusing on issues of translation or interpretation pertaining to the text. Rather, I will be engaging Phillips' account of Gaṅgeśa (hereafter Phillips) with the aim of bringing Gaṅgeśa's Jewel into contact with a debate in contemporary epistemology. I believe Gaṅgeśa's distinction between perceptual knowledge and certification has a lot to offer contemporary epistemology.The point of departure for my engagement with Phillips is the debate over internalism and externalism about knowledge.1 One account of the debate is that there is a disagreement over whether the KK principle is true. The KK principle states that when x knows that p, x knows that x knows that p. Internalists hold that knowledge is a wholly internal affair, and thus they accept the KK principle. More specifically, awareness internalists hold that x knows that p only when x is also aware of x's knowledge basis for p. By contrast, access internalists hold a weaker claim: x knows that p only when x can become aware, by reflection, of x's knowledge basis for p. Externalists typically deny some version of the KK principle. On one version of externalism, knowledge is justified true belief + some anti luck condition, and to have a justified true belief is for the belief to be formed on the basis of a reliable belief-forming process whether or not the subject knows anything about the workings of the belief-forming process. Externalists hold [End Page 486] that x can know that p, without having any reflective access to the knowledge basis for p.2 However, some analytic philosophers object to the internalismexternalism debate. In a now classic set of essays, Tyler Burge (1993, 2003) moves around the internalism-externalism debate by drawing a distinction between two types of warrant: entitlement and justification—where entitlement plays an externalist role, and justification plays an internalist role.The internalism-externalism distinction does not exist in Indian epistemology. In Indian epistemology, there is a distinction between intrinsic and extrinsic validity. This distinction only superficially resembles the internalism-externalism contrast found in the analytic tradition.3 Just as Indian epistemologists did not draw the distinction between a priori and a posteriori knowledge, they also did not draw the distinction between justification being a wholly internal affair versus justification being a wholly external affair.Can the absence of the internalism-externalism debate in classical Indian epistemology be used to draw an alternative map of epistemic relations, one that competes with Burge's distinction between entitlement and justification? Stephen Phillips' (2012) work on Nyāya epistemology in combination with his translation and commentary on Jewel allows for an opportunity to explore this question. In section II, I present Burge's account of the dual warrants of entitlement and justification. In section III, I present Phillips' account of perceptual knowledge and certified knowledge. In section IV, I use both theories to analyze a case of perceptual knowledge. In section V, I turn to a comparative analysis of Burge's and Phillips' views, to open up the issue for further debate and discussion.II. Tyler Burge on Entitlement and JustificationIn his 1993 and 2003 articles Burge offers an alternative way of seeing the internalism-externalism debate about justification. In his 1993 work he distinguishes between justification... (shrink)

Let T be a complete O-minimal theory in a language L. We first give an elementary proof of the result (due to Marker and Steinhorn) that all types over Dedekind complete models of T are definable. Let L * be L together with a unary predicate P. Let T * be the L * -theory of all pairs (N, M), where M is a Dedekind complete model of T and N is an |M| + -saturated elementary extension of N (and (...) M is the interpretation of P). Using the definability of types result, we show that T * is complete and we give a simple set of axioms for T * . We also show that for every L * -formula φ(x) there is an L-formula ψ(x) such that $T^\ast \models (\forall \mathbf{x})(P(\mathbf{x}) \rightarrow (\phi(\mathbf{x}) \mapsto \psi (\mathbf{x}))$ . This yields the following result: Let M be a Dedekind complete model of T. Let φ(x, y) be an L-formula where l(y) = k. Let $\mathbf{X} = \{X \subset M^k$ : for some a in an elementary extension N of M, X = φ (a,y N ∩ M k }. Then there is a formula ψ(y, z) of L such that X = {ψ (y, b) M : b in M}. (shrink)

Perceptual disjunctivism is a controversial thesis about perception. One familiar characterization of the thesis maintains that there is no common epistemic kind that is present in both veridical and non-veridical cases of perception. For example, the good case, in which one sees a yellow lemon, and the bad case, in which one hallucinates a yellow lemon, share a specific first-person phenomenology, being indistinguishable from the first-person point of view; however, seeing a yellow lemon and hallucinating a yellow lemon do not, (...) according to the disjunctivist, share a common epistemic kind. There are two types of disjunctivism: epistemological vs. metaphysical. John McDowell, 243–255, 2011, Philosophical Explorations, 16, 259–279, 2013) has articulated, refined, and defended one kind of disjunctivism. Tyler Burge, 1–78, 2005, Philosophical Explorations, 13, 43–80, 2011) has objected to many forms of disjunctivism, arguing that they are all inconsistent with the proximality principle in the vision sciences. PP requires an ability-general kind in common between relevantly similar perceptual states, such as seeing a yellow lemon and hallucinating a yellow lemon, which disjunctivism denies. Against the background of this debate some analytic epistemologists, such as Michael Martin, Alan Millar, 176–198, 2007), Berit Brogaard, 46–73, 2011), Duncan Pritchard, and Heather Logue, 105–133, 2013) remain attracted to some version of disjunctivism. Brogaard and Pritchard each have gone on to articulate and defend a version. Pritchard’s, for example, defends epistemological disjunctivism. Martin, Millar, and Logue, by contrast, have defended the idea that the disjunctivist is right about something, but perhaps not wholly correct about the nature of perception. In what follows, I articulate and defend the view that an interesting kind of disjunctivism is to be found through a reading of the Nyāya School of classical Indian philosophy. I articulate a version of perceptual disjunctivism informed by Nyāya perceptual theory that is not derivable from any single Nyāya philosopher. The view I offer is inspired by work on disjunctivism both in Anglo-analytic philosophy and in Nyāya scholarship, such as by Dasti and Phillips, 535–540, 2010), Ganeri, 541–550, 2010), Dasti, 1–15, 2012), Phillips, Vaidya, 562–585, 2013), and Schiller, 1–18, 2019). Importantly, the causal account I offer is distinct from Grice’s single-factor causal theory of perception by crucially involving a multi-factor causal theory of perception. My work on Nyāya perceptual theory derives primarily from Jaysankar Shaw’s account of Nyāya on the sources of knowledge, which is distinct from Stephen Phillips’ well-known account of Nyāya epistemology. Shaw’s theory has been developed and refined through textual analysis and dialectical engagement with the twentieth century Nyāya Pundit Philosopher, Viśvabandhu Tarkatīrtha. Like other modern Nyāya scholars, such as B. K. Matilal, A. Chakrabarti, 1–8, 2010), M. Chadha, J. Ganeri, and S. Phillips, 104–113, 2001, 2012), J. Shaw’s account shows how Nyāya epistemology is a living and continuing form of Indian philosophy. My goal here is twofold. On the one hand, I articulate multi-factor causal disjunctivism and show how it can be applied to the McDowell-Burge debate over the viability of disjunctivism and naïve realism. On the other hand, I aim to start a cross-cultural epistemological conversation with those that have contributed to the Anglo-analytic debate in anthologies, such as Haddock and Macpherson, Byrne and Logue, and introductions, such as Soteriou. The hope is that a cross-cultural epistemological investigation into disjunctivism will lead to better epistemic theorizing about the nature of perception. (shrink)

The "space" of Lascar strong types, on some sort and relative to a given complete theory T, is in general not a compact Hausdorff topological space. We have at least three aims in this paper. The first is to show that spaces of Lascar strong types, as well as other related spaces and objects such as the Lascar group Gal L of T, have well-defined Borel cardinalities. The second is to compute the Borel cardinalities of the known examples as well (...) as of some new examples that we give. The third is to explore notions of definable map, embedding, and isomorphism, between these and related quotient objects. We also make some conjectures, the main one being roughly "smooth if and only if trivial". The possibility of a descriptive set-theoretic account of the complexity of spaces of Lascar strong types was touched on in the paper [E. Casanovas, D. Lascar, A. Pillay and M. Ziegler, Galois groups of first order theories, J. Math. Logic1 305–319], where the first example of a "non-G-compact theory" was given. The motivation for writing this paper is partly the discovery of new examples via definable groups, in [A. Conversano and A. Pillay, Connected components of definable groups and o-minimality I, Adv. Math.231 605–623; Connected components of definable groups and o-minimality II, to appear in Ann. Pure Appl. Logic] and the generalizations in [J. Gismatullin and K. Krupiński, On model-theoretic connected components in some group extensions, preprint, arXiv:1201.5221v1]. (shrink)

This authoritative volume, written by two well-known psychologist-philosophers, presents a model of the person and its implications for psychological theory and practice. Professors Ramakrishna Rao and Anand Paranjpe draw the contours of Indian psychology, describe the methods of study, explain crucial concepts, and discuss the central ideas and their application, illustrating them with insightful case studies and judicious reviews of available research data and existing scholarly literature. The main theme is organized around the thesis that psychology is the study (...) of the person and that the person is a unique composite of body, mind and consciousness. The goal of the person is self-realization. Self-realization consists in the realization of one's true self as distinct from the manifest ego and it is facilitated by cultivating consciousness. Cultivating consciousness leads to a kind of psycho-spiritual symbiosis resulting in personal transformation, altruistic value orientation and flowering of the hidden human potential. (shrink)

Book Reviews Conrad Heilmann, Economics and Philosophy, FirstView Article.

I examine social capital’s impact on financial reports. Based on the social capital literature, I predict that the quality of the financial reports is higher when a firm is headquartered in a region with high social capital. Consistent with this prediction, I find that the firms that are headquartered in this type of region in the USA have a lower probability of committing fraud by misrepresenting financial information. Further, I find that the firms in regions with high social capital have (...) lower levels of discretionary accruals and much more readable annual reports. (shrink)

Recently, Kit Fine's (1994) view that modal truths aretrue in virtue of,grounded in, orexplained byessentialist truths has been under attack. In what follows we offer two responses to the wave of criticism against his view. While the first response is pretty straightforward, the second is based on the distinction between, what we call,Reductive Finean EssentialismandNon-Reductive Finean Essentialism. Engaging the work of Bob Hale onNon-Reductive Finean Essentialism, we aim to show that the arguments against Fine's view are unconvincing, while we acknowledge (...) the presence of a deep standoff between the two views. (shrink)

This volume provides an overview of issues arising in work on the foundations of decision theory and social choice. The collection will be of particular value to researchers in economics with interests in utility or welfare, but also to any social scientist or philosopher interested in theories of rationality or group decision-making.

Autumn Fiester's “Neglected Ends: Clinical Ethics Consultation and the Prospects for Closure” (2015) demonstrates how a focus on recommendations in clinical ethics consultations (CECs) can fail to...

This study sought to identify content on the federal budget, national debt, and budget deficit in the 12 most commonly used high school and college-leveleconomics textbooks. Our systematic review of these sources leads to two key findings: (1) Textbooks are similar in how they represent fiscal policy yet treatthe federal budget, deficit, and debt differently across the sample, and (2) Textbooks treat the federal budget, budget deficit, and national debt as theoretical, without an examination of values and systemic electoral and (...) budgetary politics. These findings lead us to argue that curriculum is needed that will permit a careful examination of how everyday citizens can gain knowledge, acknowledge values, and work towards a reasoned and realitybased view of what is at stake with regard to these issues in the 21st Century. (shrink)

When weighing up which inhaler to prescribe, a doctor may prioritise a patient’s preferences over the expected harms from the associated carbon emissions. Parker argues that this is wrong.1 Doctors have a pro-tanto duty to switch from a high-carbon metered-dose inhaler (MDI) to a low-carbon dry-powdered inhaler (DPI)—even though this provides no direct patient benefit—unless switching would undermine trust or significantly worsen a patient’s health. He goes on to state that even if DPIs are more expensive for the National Health (...) Service (NHS) then this is justified so long as it does not ‘significantly threaten’ the NHS’ ability to protect and promote health. This may appear to be a radical proposal, challenging the ethical principles of autonomy, health entitlements and justly distributed resources. However, we will claim that it is only radical in so far as one perceives (A) patient autonomy and healthcare entitlements as existing within a vacuum, unrelated to other foundational ethics concerns and (B) the health consequences of a given healthcare budget are limited solely to the designated recipients rather than all affected parties. Here, we test the claim that our responsibility for promoting patient autonomy …. (shrink)

Many medicines currently available on the market are simply too expensive for millions around the world to afford. Many medicines available in the developing world are only available to a small percentage of the population due to economic inequities. The profit-seeking behavior of pharmaceutical companies exacerbates this problem. In most cases, the price reductions required to make drugs affordable to a broader class of people in the developing world are not offset by the resultant increase in sales volume. Simply stated, (...) in most of the developing world, it is more profitable to sell drugs to the very wealthy at high prices than it is to sell cheaper drugs to a greater number of people. As a result, medicines remain unaffordable for the vast majority of people in many parts of the world. While this might be an acceptable outcome for certain commodities, such as luxury goods, it is completely unacceptable for life-saving medicines. Therefore, in order to effectively address the global lack of access to medicines, the role pharmaceutical companies play in the international intellectual property regime must be critically examined. (shrink)

Approximately two billion people lack access to medicines globally. People living with HIV, cancer patients, those suffering from tuberculosis or malaria, and other populations in desperate need of life-saving medicines are increasingly unable to access existing preventative, curative, and life-prolonging treatments. In many cases, treatment may be unavailable or inaccessible for even some of the most common and readily treatable health concerns, such as hypertension. In the developing world, many of the factors that contribute to making the world’s most vulnerable (...) and marginalized populations particularly susceptible to illness also operate to restrict their access to medicines. As a result of dramatic economic inequities and widespread poverty, it is not profitable for most originator pharmaceutical companies to develop new medicines for sale in developing markets or to lower the cost of existing drugs so that they are affordable for the majority of these populations. (shrink)

Mitos ve Logos kavramları Antik Yunan uygarlığında söz kavramına karşılık gelen sözcükleri karşılamak için kullanılmıştır. Felsefe tarihinin başlangıcı için yapılan tanımlamalarda ise mitos kavramının yerine logos kavramının tercih edilmesi iki kavram arasında bir farklılığı ortaya koymak için yapılmaktadır. Bu ayrımın nedeni ise mitos’un daha çok dinsel içerikle anılması logos’un ise içerisinde bir tür akılsallık barındırması şeklindeki yorumlarda kendini göstermektedir. Ancak söz konusu ayrımın ilk doğa filozofu/ilk felsefeci olarak nitelendirilen Thales için geçerli olup olmadığı geçmişte olduğu gibi günümüzde de halen tartışılmaktadır. (...) Felsefe tarihi yazımlarında ilk sıraya konan Thales’in anılan kavramları gerçekten farklı şekilde yorumlayıp yorumlamadığı bizce de tartışmaya açık bir husustur. Bu açıdan bakıldığında Thales, söz konusu kavramları iki farklı problemler alanı olarak mı görmüştür? Onun düşüncelerinde kendinden önceki mitolojik mirasın izleri bulunabilir mi? O, katışıksız bir rasyonel midir, yoksa henüz felsefenin yeni filizlendiği bir toplumda bir ara basamağı mı temsil etmektedir? Bu makalenin içerisinde tartışacağımız bu sorular, felsefe tarihinin başlangıcına ilişkin kavramsal arka planın ne olduğu hakkında bize katkı sağlayacaktır. (shrink)

Sen’s capabilities approach offers a radical generalisation of the conventional approach to welfare economics. It has been highly influential in development and many researchers are now beginning to explore its implications for health care. This paper contributes to the emerging debate by discussing two examples of such applications: first, at the individual decision making level, namely the right to die, and second, at the social choice level. For the first application, which draws on Nussbaum’s list of capabilities, it is argued (...) that many capabilities are ambiguously or indirectly related to the right to die, but the ability to form a concept of the good life and plan one’s own life provides a direct justification for such a right. In the second application, the focus is specifically on healthcare rationing and it is argued that, although not committed to age based rationing, the capabilities approach provides a more natural justification of age related access to health care than the fair innings argument, which is often used to justify the alleged ageism inherent in quality adjusted life years maximisation. (shrink)

There are three theories in the epistemology of modality that have received sustained attention over the past 20 years: conceivability-theory, counterfactual-theory, and deduction-theory. In this paper we argue that all three face what we call the problem of modal epistemic friction. One consequence of the problem is that for any of the three accounts to yield modal knowledge, the account must provide an epistemology of essence. We discuss an attempt to fend off the problem within the context of the internalism (...) versus externalism debate about epistemic justification. We then investigate the effects that the PMEF has on reductive and non-reductive theories of the relation between essence and modality. (shrink)

The Unified Medical Language System and the Gene Ontology are among the most widely used terminology resources in the biomedical domain. However, when we evaluate them in the light of simple principles for wellconstructed ontologies we find a number of characteristic inadequacies. Employing the theory of granular partitions, a new approach to the understanding of ontologies and of the relationships ontologies bear to instances in reality, we provide an application of this theory in relation to an example drawn from the (...) context of the pathophysiology of hypertension. This exercise is designed to demonstrate how, by taking ontological principles into account we can create more realistic biomedical ontologies which will also bring advantages in terms of efficiency and robustness of associated software applications. (shrink)

Images are an important source of data and information in the agricultural sciences. The use of image-processing techniques has outstanding implications for the analysis of agricultural operations. Fruit and vegetable classification is one of the major applications that can be utilized in supermarkets to automatically detect the kinds of fruits or vegetables purchased by customers and to determine the appropriate price for the produce. Training on-site is the underlying prerequisite for this type of arrangement, which is generally caused by the (...) users having little or no expert knowledge. We explored various methods used in addressing fruit and vegetable classification and in recognizing fruit disease problems. We surveyed image-processing approaches used for fruit disease detection, segmentation and classification. We also compared the performance of state-of-the-art methods under two scenarios, i.e., fruit and vegetable classification and fruit disease classification. The methods surveyed in this paper are able to distinguish among different kinds of fruits and their diseases that are very alike in color and texture. (shrink)

“Doğal din” terimi, bazen doğanın kendisinin ilahi olduğu bir panteistik doktrine atıfta bulunur. “Doğal teoloji” terimi ise aksine, başlangıçta gözlemlenen doğal gerçekler temelinde (ve bazen) Tanrı’nın varlığını savunmaya yönelik projeye atıfta bulunur. Bununla birlikte çağdaş felsefede, hem “doğal din” hem de “doğal teoloji” genel olarak, dinî veya teolojik konuları araştırmak için insana, “doğal” olan bilişsel yetilerini – akıl, algı, içgözlem- kullanma projesini ifade eder. Doğal din veya teoloji, mevcut anlayış üzerine, doğayla ilgili ampirik araştırmalarla sınırlı olmamakla birlikte ayrıca panteistik bir (...) sonuçla da bağlantılı değildir. Bununla birlikte o, özel doğal olmayan yetilere (ESP, telepati, mistik deneyim) veya doğaüstü bilgi kaynaklarına (kutsal metinler, vahiy teolojisi, inanç otoriteleri, doğrudan doğaüstü iletişim) hitap etmekten kaçınır. Genel olarak, doğal din veya teoloji (bundan böyle “doğal teoloji” olarak anılacaktır), diğer felsefi ve bilimsel girişimlerle aynı rasyonel inceleme standartlarına uymayı amaçlamaktadır ve aynı değerlendirme ve eleştiri yöntemlerine tabidir. (shrink)

"A rough spade for a rugged landscape" : on savage selves and more civil places -- "What remains of the harvest when the fence grazes the crop?" : on the proper violence of agrarian citizenship -- "The life of the thief leaves the belly always boiling" : on the nature and restraint of the criminal animal -- "Millets sown yield millets, evil sown yields evil" : on the moral returns of agrarian toil -- "Let the water for the paddy also (...) irrigate the grass" : on the sympathies of an aqueous self. (shrink)

Modal ontolojik argüman, Tanrı’nın varlığını sadece bilfiil gerçek olan bu dünyada değil, bütün mümkün dünyalarda göstermeye yönelik bir argümandır. Anselm’in (1033-1109) Proslogion adlı eserinin 3. bölümünde “kendisinden daha büyüğü düşünülemeyen” şeklinde tanımlanan; Tanrı’nın var olmamasının da düşünülemeyeceğini, bu yüzden de varolmamasının imkansızlığı üzerinde kurulu yeni bir argüman bulunduğunu öne süren bazı araştırmacılar, bu argümanı mümkün dünyalar semantiği yardımıyla formüle edip, “modal ontolojik argüman” şeklinde adlandırmışlardır. Çok farklı şekillerde formüle edilmiş bu argüman kabaca Tanrı’nın mümkünse zorunlu olması, dolayısıyla bilfiil gerçek olan (...) bu dünyada da var olması gerektiğini savunur. (shrink)

Studies of epistemic communities and collaborative research in the social sciences have deepened the understanding of how science works, and more specifically how the social dimensions of scientific practice both enable and impede social scientists in realizing their epistemic goals. Two types of studies of epistemic communities are distinguished: general theories of epistemic communities aim to construct accounts of theoretical change applicable to all social scientific specialties, whereas historical studies emphasize the contingencies that affect specific social scientific disciplines, subfields, or (...) institutions. Although collaborative research plays a less pronounced role in the social sciences than in the natural sciences, collaboration has enabled social scientists to investigate topics that would otherwise be difficult to investigate. (shrink)

We introduce the notion of a lovely pair of models of a simple theory T, generalizing Poizat's “belles paires” of models of a stable theory and the third author's “generic pairs” of models of an SU-rank 1 theory. We characterize when a saturated model of the theory TP of lovely pairs is a lovely pair , finding an analog of the nonfinite cover property for simple theories. We show that, under these hypotheses, TP is also simple, and we study forking (...) and canonical bases in TP. We also prove that assuming only that T is low, the existentially universal models of the universal part of a natural expansion TP+ of TP, are lovely pairs, and “simple Robinson universal domains”. (shrink)